Objective To systematically analyze the effects of chemotherapy-induced alopecia on the psychological experience of cancer patients. Methods PubMed,Web of Science,Embase,Medline,Cochrane Library,CINAHL,PsycINFO,JBI Library,CNKI,Wanfang Data,VIP Data and China Biology Medicine disc were searched to collect qualitative research on the psychological experience of cancer patients with chemotherapy-induced alopecia. The retrieval period was from inception to September 2021. The quality of studies was evaluated according to JBI Critical Appraisal Tool for qualitative research(2016). Meta-synthesis was applied to integrate the results. Results A total of 60 results were extracted from 14 studies. Similar results were summarized into 12 groups,and 3 integrated results were synthesized,including alopecia affecting both physical and mental health,taking active countermeasures,difficulties and challenges. Conclusion Alopecia affected mental health,physical health,and social relationships of cancer patients. Nurses should pay more attention to patients’ cognition and experience of alopecia,encourage patients to actively cope with it,and take corresponding interventions to help cancer patients overcome the troubles caused by alopecia,and thus enhance their quality of life.